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席广民

2018年12月27日 23:27  点击:[]

基本情况

  名:  席广民                 别:              

  位:  博士                   业:  生物化学与分子生物学  

 : 15725123910              E-mail:   475810355@qq.com

承担课题

项目编号

项目名称

位次

计划类别

起止年月

完成或进展情况

ZR2013CL018

自噬在前列腺癌发生及治疗中的作用研究

负责人

山东省自然科学基金

2013.01-2015.12

完成

J14LE52

survivin基因在紫杉醇诱导自噬过程中的作用研究

负责人

山东省教育厅科研发展计划  

2014.01-2015.12

完成

J08LG63  

Akt基因在胶质瘤中的表达及其与放射敏感性关系的研究  

负责人  

山东省教育厅科研发展计划  

2008.5-2010.10  

完成  

申请者简介

主要研究方向为细胞焦亡执行蛋白GSDMDT细胞杀伤肿瘤细胞中的作用及机制研究,肿瘤免疫耐受的分子机制研究。主持省厅级课题多项,发表SCI文章十几篇。

发表文章

1.Zhan P#, Xi GM#, Zhang B, Wu Y, Liu HB, Liu YF, Xu WJ, Zhu Q, Cai F, Zhou ZJ, Miu YY, Wang XX, Jin JJ, Li Q, Lv TF, Song Y.NCAPG2 promotes tumour proliferation by regulating G2/M phase and associates with poor prognosis in lung adenocarcinoma.

J Cell Mol Med. 2017,21(4):665-676.(IF=4.49)

2. Zhan P, Zhang B, Xi GM, Wu Y, Liu HB, Liu YF, Xu WJ, Zhu QQ, Cai F, Zhou ZJ, Miu YY, Wang XX, Jin JJ, Li Q, Qian LP, Lv TF, Song Y.PRC1 contributes to tumorigenesis of lung adenocarcinoma in association with the Wnt/β-catenin signaling pathway.Mol Cancer. 2017,16(1):108.(IF=6.2)

3. Zhan P, Xi GM, Liu HB, Liu YF, Xu WJ, Zhu Q, Zhou ZJ, Miao YY, Wang XX, Jin JJ, Lv TF, Song Y.Protein regulator of cytokinesis-1 expression: prognostic value in lung squamous cell carcinoma patients.J Thorac Dis. 2017,9(7):2054-2060.

4. Wan B, Xu WJ, Xu WN, Zhan P, Wu GN, Jin JJ, Xi GM, Yin JT, Zhang H, Chen YK, Miao YY, Wang XX, Xu YK, Lv TF, Song Y.Plasma long noncoding RNA IL-7R as a prognostic biomarker for clinical outcomes in patients with acute respiratory distress syndrome.Clin Respir J. 2017 Sep 29. doi: 10.1111/crj.12717.

5. Xi G, Wang M, Sun B, Shaikh AS, Liu Y, Wang W, Lou H, Yuan H.Targeting autophagy augments the activity of DHA-E3 to overcome p-gp mediated multi-drug resistance. Biomed Pharmacother. 2016,84:1610-1616.

6. Xi G, Hu X, Wu B, Jiang H, Young CY, Pang Y, Yuan H.Autophagy inhibition promotes paclitaxel-induced apoptosis in cancer cells. Cancer Lett. 2011 Apr 19.  (IF=6.375)

7. Xi GM, Sun B, Jiang HH, Kong F, Yuan HQ, Lou HX. Bisbibenzyl derivatives sensitize vincristine-resistant KB/VCR cells to chemotherapeutic agents by retarding P-gp activity.  Bioorg Med Chem. 2010 Sep 15;18(18):6725-33 (IF=2.93)

8. Guo DX, Xiang F, Wang XN, Yuan HQ, Xi GM, Wang YY, Yu WT, Lou HX. Labdane diterpenoids and highly methoxylated bibenzyls from the liverwort Frullania inouei. Phytochemistry. 2010 Sep;71(13):1573-8.

9. Sun B, Yuan HQ, Xi GM, Ma YD, Lou HX. Synthesis and multidrug resistance reversal activity of dihydroptychantol A and its novel derivatives. Bioorg Med Chem. 2009 Jul 15;17(14):4981-9.

10. Niu RF, Zhang L, Xi GM, Wei XY, Yang Y, Shi YR, Hao XS. Up-regulation of Twist induces angiogenesis and correlates with metastasis in hepatocellular carcinoma. J Exp Clin Cancer Res. 2007 Sep;26(3):385-94.

11. Gangmin Xi Lin Zhang Zhongli Zhan Lihua Zhang Xiyin Wei Yi Yang Yurong Shi Fei Zhang Ruifang Niu. The Effect of Twist Expression on Angiogenesis in Hepatocellular CarcinomaChinese Journal of Clinical Oncology.2006(6): 413-418.